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Article

Distinctive Klf4 mutants determine preference for DNA methylation status.

Nucleic acids research - 1 Dec 2016

Hashimoto Hideharu, Wang Dongxue, Steves Alyse N, Jin Peng, Blumenthal Robert M, Zhang Xing, Cheng Xiaodong

Abstract excerpt

Reprogramming of mammalian genome methylation is critically important but poorly understood. Klf4, a transcription factor directing reprogramming, contains a DNA binding domain with three consecutive C2H2 zinc fingers. Klf4 recognizes CpG or TpG within a specific sequence. Mouse Klf4 DNA binding domain has roughly equal affinity for methylated CpG or TpG, and slightly lower affinity for unmodified CpG. The...

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Identifiers

PMID: 27596594
DOI: 10.1093/nar/gkw774
PMCID: PMC5137437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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