Discrete somatic niches coordinate proliferation and migration of primordial germ cells via Wnt signaling

Abstract excerpt

Inheritance depends on the expansion of a small number of primordial germ cells (PGCs) in the early embryo. Proliferation of mammalian PGCs is concurrent with their movement through changing microenvironments; however, mechanisms coordinating these conflicting processes remain unclear. Here, we find that PGC proliferation varies by location rather than embryonic age. Ror2 and Wnt5a mutants with mislocalized PGCs...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Pluripotent Stem Cells Research
• Share to Renal and related cancers
• Share to Reproductive Biology and Fertility