Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila.

Cell - 28 Dec 2001

Silver D L, Montell D J

Abstract excerpt

The JAK/STAT signaling pathway, renowned for its effects on cell proliferation and survival, is constitutively active in various human cancers, including ovarian. We have found that JAK and STAT are required to convert the border cells in the Drosophila ovary from stationary, epithelial cells to migratory, invasive cells. The ligand for this pathway, Unpaired (UPD), is expressed by two central cells within the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Movement
Share to Drosophila
Share to Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Paracrine Communication

Share to Protein-Tyrosine Kinases

Share to STAT Transcription Factors

Share to Trans-Activators

Source

Identifiers

PMID: 11779460
DOI: 10.1016/s0092-8674(01)00607-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila.PMID 11779460Read ↗

The JAK/STAT pathway is required for border cell migration during Drosophila oogenesis.Semantic proximity Read ↗

Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and MetastasisSemantic proximity Read ↗

Feedback inhibition of Jak/STAT signaling by apontic is required to limit an invasive cell population.Semantic proximity Read ↗

Requirement for JAK/STAT signaling throughout border cell migration in <i>Drosophila</i>Semantic proximity Read ↗

JAK signaling is somatically required for follicle cell differentiation in Drosophila.Semantic proximity Read ↗

Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling.Semantic proximity Read ↗

Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue.Semantic proximity Read ↗

A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium.Semantic proximity Read ↗

Somatic control of germline sexual development is mediated by the JAK/STAT pathway.Semantic proximity Read ↗

JAK/STAT signaling regulates tissue outgrowth and male germline stem cell fate in DrosophilaSemantic proximity Read ↗

The<i>Drosophila</i>cytokine receptor Domeless controls border cell migration and epithelial polarization during oogenesisSemantic proximity Read ↗

Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.