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Article

Ror2 enhances polarity and directional migration of primordial germ cells.

PLoS genetics - 1 Dec 2011

Laird Diana J, Altshuler-Keylin Svetlana, Kissner Michael D, Zhou Xin, Anderson Kathryn V

Abstract excerpt

The trafficking of primordial germ cells (PGCs) across multiple embryonic structures to the nascent gonads ensures the transmission of genetic information to the next generation through the gametes, yet our understanding of the mechanisms underlying PGC migration remains incomplete. Here we identify a role for the receptor tyrosine kinase-like protein Ror2 in PGC development. In a Ror2 mouse mutant we isolated in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22216013
DOI: 10.1371/journal.pgen.1002428
PMCID: PMC3245308

Genes

PGC
ROR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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