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Article

The A1166C polymorphism of the AT1 receptor gene is associated with collagen type I synthesis and myocardial stiffness in hypertensives.

Journal of hypertension - 1 Nov 2003

Díez Javier, Laviades Concepción, Orbe Josune, Zalba Guillermo, López Begoña, González Arantxa, Mayor Gaspar, Páramo José A, Beloqui Oscar

Abstract excerpt

OBJECTIVES: We have investigated whether the A1166C polymorphism of the angiotensin II type 1 (AT1) receptor gene modulates the effects of angiotensin II on collagen type I turnover and myocardial stiffness in hypertension. METHODS: We studied 255 hypertensive patients before and after 1 year of treatment with either losartan (n = 185) or atenolol (n = 70). Serum concentrations of the carboxy-terminal propeptide...

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PMID: 14597852
DOI: 10.1097/01.hjh.0000098127.00558.d2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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