Article
Influence of angiotensin II type 1 receptor polymorphism on aortic stiffness in never-treated hypertensive patients.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 1995
Benetos A, Topouchian J, Ricard S, Gautier S, Bonnardeaux A, Asmar R, Poirier O, Soubrier F, Safar M, Cambien F
Abstract excerpt
Several clinical and experimental studies have suggested a significant role of angiotensin II in the development of alterations of small and large arteries. The present study was designed to assess the contribution of polymorphism (corresponding to an A1166-->C transversion) of the angiotensin II type 1 receptor (AT1) gene to aortic stiffness. One hundred thirty-four never-treated hypertensive patients were...
Topics
- Adult
- Aged
- Analysis of Variance
- Angiotensin II
- Aorta
- Blood Flow Velocity
- Blood Pressure
- Cholesterol, HDL
- Data Interpretation, Statistical
- Diastole
- Female