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Article

An archaeal endoribonuclease catalyzes cis- and trans- nonspliceosomal splicing in mouse cells.

Nature biotechnology - 1 Dec 2003

Deidda Giancarlo, Rossi Nicoletta, Tocchini-Valentini Glauco P

Abstract excerpt

The tRNA endonuclease from the archaebacterium Methanococcus jannaschii (MJ endonuclease) can cleave RNAs forming specific bulge-helix-bulge (BHB) structures recognized by the enzyme. The resulting cleavage products are subsequently joined together by an endogenous ligase. We demonstrate the potential of using this strategy for repairing RNA in higher organisms by expressing the enzyme in mouse cells. Reporter...

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PMID: 14595336
DOI: 10.1038/nbt908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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