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Minigenes enhance heterologous expression and prevent aberrant splicing of mouse Spink1

2 Aug 2025

Abstract excerpt

The digestive enzyme trypsin is an important driver of pancreatitis development and progression. Inhibition of intrapancreatic trypsin activity is an attractive yet so far unsuccessful approach for the treatment and prevention of pancreatitis. Gene therapy using adeno-associated viral vector containing the human serine protease inhibitor Kazal type 1 (SPINK1) gene has shown efficacy against murine pancreatitis in...

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PMID: 40753100
DOI: 10.1038/s41598-025-13128-7

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