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Induction of fibroblast apolipoprotein E expression during apoptosis, starvation-induced growth arrest and mitosis

15 Mar 2004

Abstract excerpt

Apolipoprotein E (apoE) mediates the hepatic clearance of plasma lipoproteins, facilitates cholesterol efflux from macrophages and aids neuronal lipid transport. ApoE is expressed at high levels in hepatocytes, macrophages and astrocytes. In the present study, we identify nuclear and cytosolic pools of apoE in human fibroblasts. Fibroblast apoE mRNA and protein levels were up-regulated during...

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PMID: 14656220
DOI: 10.1042/bj20031352

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