Article
Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse.
Science (New York, N.Y.) - 19 Dec 2003
Serizawa Shou, Miyamichi Kazunari, Nakatani Hiroko, Suzuki Misao, Saito Michiko, Yoshihara Yoshihiro, Sakano Hitoshi
Abstract excerpt
In the mouse olfactory system, each olfactory sensory neuron (OSN) expresses only one odorant receptor (OR) gene in a monoallelic and mutually exclusive manner. Such expression forms the genetic basis for OR-instructed axonal projection of OSNs to the olfactory bulb of the brain during development. Here, we identify an upstream cis-acting DNA region that activates the OR gene cluster in mouse and allows the...
Topics
- Alleles
- Animals
- Axons
- Chromosomes, Artificial, Yeast
- Conserved Sequence
- Feedback, Physiological
- Frameshift Mutation
- Gene Expression Regulation
- Gene Silencing
- In Situ Hybridization
- Locus Control Region
- Mice
- Mice, Transgenic