Article
Antithrombotic Therapy on Antithrombin Resistance in a Mouse Model.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2026
Suzuki Nobuaki, Suzuki Atsuo, Tamura Shogo, Tokumaru Sena, Notoh Hinako, Takagi Akira, Suzuki Sachiko, Isotani Ayako, Suzuki Naruko, Okamoto Shuichi, Kanematsu Takeshi, Ikawa Masahito, Hayakawa Fumihiko, Kiyoi Hitoshi, Kojima Tetsuhito, Matsushita Tadashi
Abstract excerpt
BACKGROUND: Antithrombin resistance (ATR) is a congenital thrombotic predisposition caused by abnormal prothrombin, FII (Factor II). Abnormal FII with ATR characteristics, when converted to thrombin, FIIa (Factor IIa), shows a reduced affinity of binding to AT (antithrombin), resulting in reduced anti-FIIa and a thrombotic tendency. Data on the efficacy of anticoagulants in ATR are currently insufficient....
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