Article
Heterozygous antithrombin deficiency improves in vivo haemostasis in factor VIII-deficient mice.
Thrombosis and haemostasis - 1 Jun 2010
Bolliger Daniel, Szlam Fania, Suzuki Nobuaki, Matsushita Tadashi, Tanaka Kenichi A
Abstract excerpt
Decreased levels of factor VIII (FVIII) limit the amount of thrombin generated at the site of injury, but not the rate that thrombin is neutralised by antithrombin (AT). We hypothesised that FVIII-deficient mice with heterozygous AT deficiency will demonstrate increased thrombin generation and therefore less in vivo bleeding compared to FVIII-deficient mice with normal AT levels. Therefore, we performed tail...
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