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Article

Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions.

The Journal of experimental medicine - 2 Aug 2004

Schrader Carol E, Vardo Joycelyn, Linehan Erin, Twarog Michael Z, Niedernhofer Laura J, Hoeijmakers Jan H J, Stavnezer Janet

Abstract excerpt

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway. ERCC1-XPF nicks double-stranded DNA immediately adjacent to 3' single-strand regions. Substrates include DNA bubbles and flaps. Furthermore, ERCC1 interacts with Msh2, a mismatch repair (MMR) protein involved in class switch recombination (CSR). Therefore, ERCC1-XPF has abilities that might be...

Read the complete abstract on PubMed

Topics

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Share to Base Pair Mismatch
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endonucleases

Share to Immunoglobulin Class Switching

Share to Mice, Inbred C57BL

Share to MutS Homolog 2 Protein

Share to Proto-Oncogene Proteins

Share to Recombination, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 15280420
DOI: 10.1084/jem.20040052
PMCID: PMC2211985

Genes

ERCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions.PMID 15280420Read ↗

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