Article
Isolation and characterization of a brefeldin A-resistant mutant of monkey kidney Vero cells.
Experimental cell research - 1 Dec 1992
Chen C H, Kuwazuru Y, Yoshida T, Nambiar M, Wu H C
Abstract excerpt
Brefeldin A (BFA) is a fungal antibiotic which disrupts protein transport between the endoplasmic reticulum and the Golgi. A BFA-resistant mutant of monkey kidney Vero cells, BER-40, which exhibited about a 90-fold increase in the LD50 of BFA (5.2 ng/ml for Vero cells versus 460 ng/ml for BER-40 cells), has been isolated. The increased resistance of BER-40 cells toward BFA was also manifested in a greatly reduced...
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