Article
Partial phenotypic suppression of a peroxisome-deficient animal cell mutant treated with aminoglycoside G418.
The Journal of biological chemistry - 5 Jul 1992
Allen L A, Raetz C R
Abstract excerpt
Certain enzymes normally associated with peroxisomes, such as the dihydroxyacetone phosphate (DHAP) acyltransferase involved in plasmalogen biosynthesis, are present at low levels in peroxisome-deficient mutants of Chinese hamster ovary (CHO) cells. We now show that the aminoglycoside G418 increases the residual DHAP acyltransferase in mutant ZR-82 by 60-fold. This is accompanied by a dose- and time-dependent...
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