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Article

Partial phenotypic suppression of a peroxisome-deficient animal cell mutant treated with aminoglycoside G418.

The Journal of biological chemistry - 5 Jul 1992

Allen L A, Raetz C R

Abstract excerpt

Certain enzymes normally associated with peroxisomes, such as the dihydroxyacetone phosphate (DHAP) acyltransferase involved in plasmalogen biosynthesis, are present at low levels in peroxisome-deficient mutants of Chinese hamster ovary (CHO) cells. We now show that the aminoglycoside G418 increases the residual DHAP acyltransferase in mutant ZR-82 by 60-fold. This is accompanied by a dose- and time-dependent...

Topics

Acyltransferases
Animals
Autoradiography
CHO Cells
Chromatography, Thin Layer
Cricetinae
Cricetulus
Gentamicins
Microbodies
Microscopy, Fluorescence
Oxidation-Reduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Phospholipids

Plasmalogens

Source

Identifiers

PMID: 1618823

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1618823-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Partial phenotypic suppression of a peroxisome-deficient animal cell mutant treated with aminoglycoside G418.PMID 1618823Read ↗

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