Article
Characterization of the cytochrome P450 isozyme that metabolizes ochratoxin A, using metabolic inducers, inhibitors and antibodies.
IARC scientific publications - 1 Jan 1991
Hietanen E, Bartsch H, Béréziat J C, Castegnaro M, Michelon J
Abstract excerpt
The phenotypic pattern of drug biotransformation is determined by both host and environmental factors. Debrisoquine is a good probe for phenotyping individuals, as its metabolism is not affected by age, gender, smoking habits or alcohol intake. People with Balkan endemic nephropathy or with urina...
Topics
- Animals
- Antibodies, Monoclonal
- Benzoflavones
- Cytochrome P-450 CYP1A2
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System
- Enzyme Induction
- Isoenzymes
- Male
- Metyrapone
- Mice
- Microsomes, Liver
- Mixed Function Oxygenases
- Ochratoxins
- Oxidoreductases
- Phenotype
- Polymorphism, Genetic