Regulation of the murine TRACP gene promoter.

doi:10.1359/jbmr.2003.18.10.1901

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Article

Regulation of the murine TRACP gene promoter.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2003

Cassady A I, Luchin A, Ostrowski M C, Hume D A

Abstract excerpt

The activity of the TRACP promoter has been investigated as a model of gene regulation in osteoclasts. The murine TRACP gene promoter contains potential binding sites for a number of transcription factors in particular, candidate sites for the Ets factor PU.1 and for the microphthalmia transcription factor (MiTF). These are of relevance to osteoclast biology because the PU.1 knockout mouse has an osteopetrotic...

Topics

Acid Phosphatase
Animals
Binding Sites
Cell Line
DNA-Binding Proteins
Gene Expression Regulation
Genes, Reporter
Isoenzymes
Luciferases
Mice
Mice, Knockout
Microphthalmia-Associated Transcription Factor
Osteopetrosis
Phenotype
Promoter Regions, Genetic
Proto-Oncogene Proteins
Tartrate-Resistant Acid Phosphatase
Trans-Activators

Source

Open in PubMed

Identifiers

PMID: 14584903
DOI: 10.1359/jbmr.2003.18.10.1901

Provenance

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