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Article

Characterization of the mouse tartrate-resistant acid phosphatase (TRAP) gene promoter.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 1995

Reddy S V, Hundley J E, Windle J J, Alcantara O, Linn R, Leach R J, Boldt D H, Roodman G D

Abstract excerpt

Tartrate-resistant acid phosphatase (TRAP) is an iron-binding protein that is highly expressed in osteoclasts. To characterize the regulation of TRAP gene expression, progressive 5' and 3' deletions of a 1.8 kb fragment containing the 5'-flanking sequence were fused to a luciferase reporter gene. Two nonoverlapping regions of this 1.8 kb fragment had promoter activity. The upstream promoter (P1) was located...

Topics

Acid Phosphatase
Animals
Base Sequence
Cell Line
DNA Primers
Endometrium
Female
Gene Expression Regulation, Enzymologic
Genes, Reporter
Isoenzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Luciferases

Mice

Molecular Sequence Data

Molecular Weight

Mutation

Osteoclasts

Polymerase Chain Reaction

Promoter Regions, Genetic

Source

Identifiers

PMID: 7610931
DOI: 10.1002/jbmr.5650100413

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7610931-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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