Article
Characterization of the mouse tartrate-resistant acid phosphatase (TRAP) gene promoter.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 1995
Reddy S V, Hundley J E, Windle J J, Alcantara O, Linn R, Leach R J, Boldt D H, Roodman G D
Abstract excerpt
Tartrate-resistant acid phosphatase (TRAP) is an iron-binding protein that is highly expressed in osteoclasts. To characterize the regulation of TRAP gene expression, progressive 5' and 3' deletions of a 1.8 kb fragment containing the 5'-flanking sequence were fused to a luciferase reporter gene. Two nonoverlapping regions of this 1.8 kb fragment had promoter activity. The upstream promoter (P1) was located...
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