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Mitf Induction by RANKL Is Critical for Osteoclastogenesis

31 Mar 2010

Abstract excerpt

Microphthalmia-associated transcription factor (Mitf) regulates the development and function of several cell lineages, including osteoclasts. In this report, we identified a novel mechanism by which RANKL regulates osteoclastogenesis via induction of Mitf isoform E (Mitf-E). Both Mitf-A and Mitf-E are abundantly present in osteoclasts. Unlike Mitf-A, which is ubiquitously expressed and is present in similar...

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PMID: 20357005
DOI: 10.1091/mbc.e09-07-0584

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