Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation.

The Journal of biological chemistry - 28 Sept 2001

Luchin A, Suchting S, Merson T, Rosol T J, Hume D A, Cassady A I, Ostrowski M C

Abstract excerpt

The microphthalmia transcription factor (MITF), a basic-helix-loop-helix zipper factor, regulates distinct target genes in several cell types. We hypothesized that interaction with the Ets family factor PU.1, whose expression is limited to hematopoietic cells, might be necessary for activation of target genes like tartrate-resistant acid phosphatase (TRAP) in osteoclasts. Several lines of evidence were consistent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to COS Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luciferases

Share to Microphthalmia-Associated Transcription Factor

Share to Osteoclasts

Share to Sequence Homology, Nucleic Acid

Share to Trans-Activators

Share to Transcriptional Activation

Source

Identifiers

PMID: 11481336
DOI: 10.1074/jbc.M106418200

Genes

MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation.PMID 11481336Read ↗

Microphthalmia Transcription Factor and PU.1 Synergistically Induce the Leukocyte Receptor Osteoclast-associated Receptor Gene ExpressionSemantic proximity Read ↗

The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts.Semantic proximity Read ↗

Regulation of the murine TRACP gene promoter.Semantic proximity Read ↗

Defective co-activator recruitment in osteoclasts from microphthalmia-oak ridge mutant mice.Semantic proximity Read ↗

Failure to Target RANKL Signaling Through p38-MAPK Results in Defective Osteoclastogenesis in the Microphthalmia Cloudy-Eyed Mutant.Semantic proximity Read ↗

The novel mouse microphthalmia mutations Mitfmi-enu5 and Mitfmi-bcc2 produce dominant negative Mitf proteins.Semantic proximity Read ↗

The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor.Semantic proximity Read ↗

Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMBSemantic proximity Read ↗

Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein.Semantic proximity Read ↗

Melanocytes and the microphthalmia transcription factor network.Semantic proximity Read ↗

Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development.Semantic proximity Read ↗

Genomic, transcriptional and mutational analysis of the mouse microphthalmia locus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.