Article
Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9).
Pharmacogenetics - 1 Nov 2003
Kiyotani Kazuma, Yamazaki Hiroshi, Fujieda Masaki, Iwano Shunsuke, Matsumura Keiko, Satarug Soisungwan, Ujjin Pailin, Shimada Tsutomu, Guengerich F Peter, Parkinson Andrew, Honda Goro, Nakagawa Kazuko, Ishizaki Takashi, Kamataki Tetsuya
Abstract excerpt
One of seven poor metabolizers of coumarin found in Thai subjects was previously genotyped as heterozygote for the CYP2A6*4 (whole deletion) and CYP2A6*9. Thus, we aimed to investigate the relationship between the genetic polymorphism in the TATA box of the CYP2A6 gene (CYP2A6*9), expression levels of CYP2A6 mRNA and coumarin 7-hydroxylase activities in human livers. Levels of CYP2A6 mRNA were quantified by...
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