Article
Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females.
Pharmacogenetics - 1 Apr 2002
Ujjin Pailin, Satarug Soisungwan, Vanavanitkun Yuvaree, Daigo Satoshi, Ariyoshi Noritaka, Yamazaki Hiroshi, Reilly Paul E B, Moore Michael R, Kamataki Tetsuya
Abstract excerpt
The relationships between catalytic activity of cytochrome P450 2A6 (CYP2A6), polymorphism of CYP2A6 gene, gender and levels of body iron stores were analysed in a sample group of 202 apparently healthy Thais, aged 19-47 years. Eleven individuals were found to have high activity of CYP2A6, judged by the relatively large amounts (11.2-14.6 mg) of 7-hydroyxcoumarin (7-OHC) excreted 3 h following administration of...
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