Article
Effects of polymorphism in promoter region of human CYP2A6 gene (CYP2A6*9) on expression level of messenger ribonucleic acid and enzymatic activity in vivo and in vitro.
Clinical pharmacology and therapeutics - 1 Jul 2003
Yoshida Ryoko, Nakajima Miki, Nishimura Kiyoko, Tokudome Shogo, Kwon Jun-Tack, Yokoi Tsuyoshi
Abstract excerpt
Cytochrome P450 (CYP) 2A6 catalyzes nicotine C-oxidation, leading to cotinine formation, a major metabolic pathway of nicotine in humans. There are genetic polymorphisms in the human CYP2A6 gene. Previously, we demonstrated that in vivo nicotine metabolism is impaired with the CYP2A6*4, CYP2A6*7,...
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