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Article

Ring of negative charge in BK channels facilitates block by intracellular Mg2+ and polyamines through electrostatics.

The Journal of general physiology - 1 Aug 2006

Zhang Yaxia, Niu Xiaowei, Brelidze Tinatin I, Magleby Karl L

Abstract excerpt

Intracellular Mg2+ and natural polyamines block outward currents in BK channels in a highly voltage-dependent manner. Here we investigate the contribution of the ring of eight negatively charged residues (4 x E321/E324) at the entrance to the inner vestibule of BK channels to this block. Channels with or without (E321N/E324N) the ring of negative charge were expressed in oocytes and unitary currents were recorded...

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Identifiers

PMID: 16847096
DOI: 10.1085/jgp.200609493
PMCID: PMC2151526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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