Article
The Rab8 GTPase selectively regulates AP-1B-dependent basolateral transport in polarized Madin-Darby canine kidney cells.
The Journal of cell biology - 27 Oct 2003
Ang Agnes Lee, Fölsch Heike, Koivisto Ulla-Maija, Pypaert Marc, Mellman Ira
Abstract excerpt
The AP-1B clathrin adaptor complex plays a key role in the recognition and intracellular transport of many membrane proteins destined for the basolateral surface of epithelial cells. However, little is known about other components that act in conjunction with AP-1B. We found that the Rab8 GTPase is one such component. Expression of a constitutively activated GTP hydrolysis mutant selectively inhibited basolateral...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.