Article
Rab8 regulates basolateral secretory, but not recycling, traffic at the recycling endosome.
Molecular biology of the cell - 1 May 2008
Henry Lauren, Sheff David R
Abstract excerpt
Rab8 is a monomeric GTPase that regulates the delivery of newly synthesized proteins to the basolateral surface in polarized epithelial cells. Recent publications have demonstrated that basolateral proteins interacting with the mu1-B clathrin adapter subunit pass through the recycling endosome (RE) en route from the TGN to the plasma membrane. Because Rab8 interacts with these basolateral proteins, these findings...
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