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Article

rab4 regulates transport to the apical plasma membrane in Madin-Darby canine kidney cells.

The Journal of biological chemistry - 22 Mar 2002

Mohrmann Karin, Leijendekker Richtje, Gerez Lisya, van Der Sluijs Peter

Abstract excerpt

The small GTPase rab4 is associated with early endosomes and regulates membrane recycling in fibroblasts. rab4 is present in epithelial cells; however, neither its localization nor function has been established in this cell type. We transfected Madin-Darby canine kidney cells with rab4, the GTPase-deficient mutant rab4Q67L, and the dominant negative mutant rab4S22N that poorly binds guanine nucleotides. Confocal...

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Identifiers

PMID: 11790789
DOI: 10.1074/jbc.M111237200

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