Article
Modulation of endocytic traffic in polarized Madin-Darby canine kidney cells by the small GTPase RhoA.
Molecular biology of the cell - 1 Dec 1999
Leung S M, Rojas R, Maples C, Flynn C, Ruiz W G, Jou T S, Apodaca G
Abstract excerpt
Efficient postendocytic membrane traffic in polarized epithelial cells is thought to be regulated in part by the actin cytoskeleton. RhoA modulates assemblies of actin in the cell, and it has been shown to regulate pinocytosis and phagocytosis; however, its effects on postendocytic traffic are largely unexplored. To this end, we expressed wild-type RhoA (RhoAWT), dominant active RhoA (RhoAV14), and dominant...
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