Transfection of <i>Keratin 18</i> Gene in Human Breast Cancer Cells Causes Induction of Adhesion Proteins and Dramatic Regression of Malignancy <i>In vitro</i> and <i>In vivo</i>

Abstract excerpt

This study shows that high keratin 18 (K18) expression in tumor cells is associated with reduced invasiveness in vitro and lack of tumorigenicity in nude mice. We previously showed that high K18 expression correlated with a good prognosis and that reducing K18 expression increased the aggressiveness of established breast cancer cell lines. To confirm these observations, we transfected the human K18 gene into the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hair Growth and Disorders
• Share to Skin and Cellular Biology Research
• Share to Wnt/β-catenin signaling in development and cancer