Article
Reduced ING1b gene expression plays an important role in carcinogenesis of non-small cell lung cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2003
Kameyama Kotaro, Huang Cheng-long, Liu Dage, Masuya Daiki, Nakashima Takashi, Sumitomo Shinichi, Takami Yuji, Kinoshita Moritoshi, Yokomise Hiroyasu
Abstract excerpt
PURPOSE: We performed a clinical study on ING1b gene expression and p53 gene status in relation to p53 target genes. EXPERIMENTAL DESIGN: Eighty-eight tumors from surgically treated non-small cell lung cancer (NSCLC) patients were studied. PCR-single-strand conformational polymorphism after sequencing was performed to investigate ING1 and p53 gene status. Quantitative reverse transcription-PCR was performed to...
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