Article
Analyses of the tumour suppressor ING1 expression and gene mutation in human basal cell carcinoma.
International journal of oncology - 1 Apr 2003
Chen Bin, Campos Eric I, Crawford Richard, Martinka Magdalena, Li Gang
Abstract excerpt
The incidence of basal cell carcinoma is the highest among all human malignancies. Epidemiological evidence indicates that ultraviolet radiation is the primary environmental cause for the pathogenesis of basal cell carcinoma. However, the genetic changes caused by ultraviolet radiation that lead to basal cell carcinoma formation remain unclear. We and others have demonstrated that the ING1 (inhibitor of growth 1)...
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