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Article

The Anoikis Effector Bit1 Displays Tumor Suppressive Function in Lung Cancer Cells

8 Jul 2014

Abstract excerpt

The mitochondrial Bit1 (Bcl-2 inhibitor of transcription 1) protein is a part of an apoptotic pathway that is uniquely regulated by integrin-mediated attachment. As an anoikis effector, Bit1 is released into the cytoplasm following loss of cell attachment and induces a caspase-independent form of apoptosis. Considering that anoikis resistance is a critical determinant of transformation, we hypothesized that...

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PMID: 25003198
DOI: 10.1371/journal.pone.0101564

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