Article
Lack of parental origin specificity of altered alleles at 11p15 in testicular germ cell tumors.
Cancer genetics and cytogenetics - 1 Nov 2003
Kraggerud Sigrid M, Lee Maxwell P, Skotheim Rolf I, Stenwig Anna E, Fosså Sophie D, Feinberg Andrew P, Lothe Ragnhild A
Abstract excerpt
Allelic imbalance (AI) at loci on chromosome 11 has been shown in several types of human solid tumors, including testicular germ cell tumors (TGCTs). In this study we have focused on the 11p15 region, which is known for its high density of imprinted genes. Highly polymorphic microsatellite markers were analyzed in a series of 71 TGCTs, and AI was observed in 28 of the tumors (39%) at one or more of the loci...
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