Article
Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5.
Oncogene - 21 Mar 1996
Kondo M, Matsuoka S, Uchida K, Osada H, Nagatake M, Takagi K, Harper J W, Takahashi T, Elledge S J, Takahashi T
Abstract excerpt
Genomic imprinting at 11p15 is suggested to play a role in certain pediatric tumors such as Wilms' tumor, based on the findings of selective maternal loss of this chromosomal region. Although the allele loss at 11p15 is also frequent in a number of cancers of adults including lung, breast, and bl...
Topics
- Adult
- Alleles
- Amino Acid Sequence
- Base Sequence
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Small Cell
- Chromosomes, Human, Pair 11
- Cyclin-Dependent Kinase Inhibitor p57
- Female
- Gene Deletion
- Genomic Imprinting
- Humans
- Lung
- Lung Neoplasms
- Molecular Sequence Data
- Mothers
- Mutation
- Nuclear Proteins