Article
Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase.
Cancer letters - 10 Nov 2003
Ahsan Habibul, Chen Yu, Kibriya Muhammad G, Islam Mohammad N, Slavkovich Vesna N, Graziano Joseph H, Santella Regina M
Abstract excerpt
Chronic exposure to inorganic arsenic is known to cause non-melanocytic skin and internal cancers in humans. We examined whether genetic susceptibility, as determined by single nucleotide polymorphisms -463G-->A and -262C-->T in the oxidative stress genes myeloperoxidase (MPO) and catalase (CAT), respectively, are associated with the risk of arsenic-induced hyperkeratotic skin lesions-precursors of skin cancer-in...
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