Article
Genetic variants associated with arsenic susceptibility: study of purine nucleoside phosphorylase, arsenic (+3) methyltransferase, and glutathione S-transferase omega genes.
Environmental health perspectives - 1 Apr 2008
De Chaudhuri Sujata, Ghosh Pritha, Sarma Nilendu, Majumdar Papiya, Sau Tanmoy Jyoti, Basu Santanu, Roychoudhury Susanta, Ray Kunal, Giri Ashok K
Abstract excerpt
BACKGROUND: Individual variability in arsenic metabolism may underlie individual susceptibility toward arsenic-induced skin lesions and skin cancer. Metabolism of arsenic proceeds through sequential reduction and oxidative methylation being mediated by the following genes: purine nucleoside phosphorylase (PNP), arsenic (+3) methyltransferase (As3MT), glutathione S-transferase omega 1 (GSTO1), and omega 2 (GSTO2)....
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