Article
A case-control study of GST polymorphisms and arsenic related skin lesions.
Environmental health : a global access science source - 6 Feb 2007
McCarty Kathleen M, Ryan Louise, Houseman E Andres, Williams Paige L, Miller David P, Quamruzzaman Quazi, Rahman Mahmuder, Mahiuddin Golam, Smith Thomas, Gonzalez Ernesto, Su Li, Christiani David C
Abstract excerpt
BACKGROUND: Polymorphisms in GSTT1, GSTM1 and GSTP1 impact detoxification of carcinogens by GSTs and have been reported to increase susceptibility to environmentally related health outcomes. Individual factors in arsenic biotransformation may influence disease susceptibility. GST activity is involved in the metabolism of endogenous and exogenous compounds, including catalyzing the formation of arsenic-GSH...
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