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Article

Targeted gene knockdown in zebrafish using negatively charged peptide nucleic acid mimics.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Nov 2003

Urtishak Karen A, Choob Michael, Tian Xiaobing, Sternheim Nitzan, Talbot William S, Wickstrom Eric, Farber Steven A

Abstract excerpt

Negatively charged homo-oligomers of alternating trans-4-hydroxy-L-proline/phosphonate polyamides with DNA bases (HypNA-pPNA) display excellent hybridization properties toward DNA and RNA, while preserving the mismatch discrimination, nuclease resistance, and protease resistance of peptide nucleic acids (PNAs). Similar properties are associated with morpholino phosphorodiamidate (MO) DNA mimics, which have been...

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PMID: 14579379
DOI: 10.1002/dvdy.10394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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