In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus.

doi:10.1128/AAC.00069-07

Article

In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus.

Antimicrobial agents and chemotherapy - 1 Jul 2007

Deas Tia S, Bennett Corey J, Jones Susan A, Tilgner Mark, Ren Ping, Behr Melissa J, Stein David A, Iversen Patrick L, Kramer Laura D, Bernard Kristen A, Shi Pei-Yong

Abstract excerpt

We characterize in vitro resistance to and demonstrate the in vivo efficacy of two antisense phosphorodiamidate morpholino oligomers (PMOs) against West Nile virus (WNV). Both PMOs were conjugated with an Arg-rich peptide. One peptide-conjugated PMO (PPMO) binds to the 5' terminus of the viral genome (5'-end PPMO); the other targets an essential 3' RNA element required for genome cyclization (3' conserved...

Topics

Animals
Antiviral Agents
Arginine
Base Sequence
Cell Line
Chlorocebus aethiops
Codon
Conserved Sequence
Cricetinae
Dose-Response Relationship, Drug

Female

In Vitro Techniques

Injections, Intraperitoneal

Injections, Subcutaneous

Kidney

Kinetics

Mice

Mice, Inbred C3H

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