Article

A side-by-side comparison of peptide-delivered antisense antibiotics employing different nucleotide mimics

2023-07-11

Abstract excerpt

<h4>ABSTRACT</h4> Antisense oligomer (ASO)-based antibiotics that target mRNAs of essential bacterial genes have great potential for counteracting antimicrobial resistance and for precision microbiome editing. To date, the development of such antisense antibiotics has primarily focused on using phosphorodiamidate morpholino (PMO) and peptide nucleic acid (PNA) backbones, largely ignoring the growing number of che...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 518d18ec-593c-5ab5-811f-af79e0e0c31e
DOI: 10.1101/2023.07.11.548539

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A side-by-side comparison of peptide-delivered antisense antibiotics employing different nucleotide mimicsDOI 10.1101/2023.07.11.548539Read

An antisense oligomer conjugate with unpredicted bactericidal activity against <i>Fusobacterium nucleatum</i>Semantic proximity Read

Silencing Antibiotic Resistance with Antisense OligonucleotidesSemantic proximity Read

Gene-specific effects of antisense phosphorodiamidate morpholino oligomer-peptide conjugates on Escherichia coli and Salmonella enterica serovar typhimurium in pure culture and in tissue culture.Semantic proximity Read

Antisense Oligonucleotides: Technological Advances, Clinical Progress, and Expanding Therapeutic FrontiersSemantic proximity Read

Small Drugs, Huge Impact: The Extraordinary Impact of Antisense Oligonucleotides in Research and Drug DevelopmentSemantic proximity Read

Antisense oligonucleotide: A promising therapeutic option to beat COVID ‐19Semantic proximity Read

Clinical Applications of Single-Stranded Oligonucleotides: Current Landscape of Approved and In-Development TherapeuticsSemantic proximity Read

Antisense Oligonucleotide-Based Therapy of Viral InfectionsSemantic proximity Read

A systematic identification of resistance determinants to antisense antibiotics suggests adaptation strategies dependent on the delivery peptide.Semantic proximity Read

A systematic identification of resistance determinants to antisense antibiotics suggests adaptation strategies dependent on the delivery peptideSemantic proximity Read

AcrAB–TolC Inhibition by Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Restores Antibiotic Activity in Vitro and in VivoSemantic proximity Read

Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomersSemantic proximity Read