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Article

Bacterial resistance to antisense peptide phosphorodiamidate morpholino oligomers.

Antimicrobial agents and chemotherapy - 1 Dec 2012

Puckett Susan E, Reese Kaleb A, Mitev Georgi M, Mullen Valerie, Johnson Rudd C, Pomraning Kyle R, Mellbye Brett L, Tilley Lucas D, Iversen Patrick L, Freitag Michael, Geller Bruce L

Abstract excerpt

Peptide phosphorodiamidate morpholino oligomers (PPMOs) are synthetic DNA mimics that bind cRNA and inhibit bacterial gene expression. The PPMO (RFF)(3)RXB-AcpP (where R is arginine, F, phenylalanine, X is 6-aminohexanoic acid, B is β-alanine, and AcpP is acyl carrier protein) is complementary to 11 bases of the essential gene acpP (which encodes acyl carrier protein). The MIC of (RFF)(3)RXB-AcpP was 2.5 μM (14...

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Identifiers

PMID: 22985881
DOI: 10.1128/AAC.00850-12
PMCID: PMC3497173

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Source receipt: pubmed, retrieved 7 Sept 2026.

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