Article
Two highly divergent ancient allelic lineages of the transporter associated with antigen processing (TAP) gene in Xenopus: further evidence for co-evolution among MHC class I region genes.
European journal of immunology - 1 Nov 2003
Ohta Yuko, Powis Simon J, Lohr Rebecca L, Nonaka Masaru, Pasquier Louis Du, Flajnik Martin F
Abstract excerpt
In the frog Xenopus, MHC class I antigen presentation and processing genes (the immunoproteasome LMP2 and LMP7 and the transporter TAP1 and TAP2) seem to be closely linked in a primordial organization. Two distinct lineages of class Ia and LMP7 loci were previously identified, thus strongly suggesting co-evolution among 'class I region' genes. We now show that the Xenopus MHC 'class I region' lies between class...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Cysteine Endopeptidases
- DNA-Binding Proteins
- Evolution, Molecular
- Genetic Linkage
- Histocompatibility Antigens Class I
- Molecular Sequence Data
- Multienzyme Complexes