Article
An evolutionary analysis of antigen processing and presentation across different timescales reveals pervasive selection.
PLoS genetics - 1 Mar 2014
Forni Diego, Cagliani Rachele, Tresoldi Claudia, Pozzoli Uberto, De Gioia Luca, Filippi Giulia, Riva Stefania, Menozzi Giorgia, Colleoni Marta, Biasin Mara, Lo Caputo Sergio, Mazzotta Francesco, Comi Giacomo P, Bresolin Nereo, Clerici Mario, Sironi Manuela
Abstract excerpt
The antigenic repertoire presented by MHC molecules is generated by the antigen processing and presentation (APP) pathway. We analyzed the evolutionary history of 45 genes involved in APP at the inter- and intra-species level. Results showed that 11 genes evolved adaptively in mammals. Several positively selected sites involve positions of fundamental importance to the protein function (e.g. the TAP1...
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