Article
Trans-species polymorphism of the major histocompatibility complex-encoded proteasome subunit LMP7 in an amphibian genus, Xenopus.
Immunogenetics - 1 Mar 2000
Nonaka M, Yamada-Namikawa C, Flajnik M F, Du Pasquier L
Abstract excerpt
LMP7 (PSMB8) is a major histocompatibility complex (MHC)-encoded catalytic subunit of 20S immunoproteasome, which is responsible for the production of antigenic peptide to be presented by the MHC class I molecules. Two highly diverged allelic lineages of LMP7, termed LMP7A and LMP7B, have been identified previously in an amphibian, Xenopus laevis. Fourteen Xenopus species were analyzed by genomic Southern...
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