Article
Nasopharyngeal carcinoma and genetic polymorphisms of DNA repair enzymes XRCC1 and hOGG1.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2003
Cho En-Yu, Hildesheim Allan, Chen Chien-Jen, Hsu Mow-Ming, Chen I-How, Mittl Beth F, Levine Paul H, Liu Mei-Ying, Chen Jen-Yang, Brinton Louise A, Cheng Yu-Juen, Yang Czau-Siung
Abstract excerpt
Nitrosamine consumption and polymorphisms in CYP2E1, the product of which is involved in the activation of nitrosamines into reactive intermediates, have been shown to be associated with nasopharyngeal carcinoma (NPC) risk. Given that reactive intermediates created during nitrosamine metabolism are capable of DNA damage, we further hypothesized that differences between individuals in their ability to repair DNA...
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