Article
The human OGG1 DNA repair enzyme and its association with orolaryngeal cancer risk.
Carcinogenesis - 1 Jul 2002
Elahi Abul, Zheng Zhong, Park Jong, Eyring Kathy, McCaffrey Thomas, Lazarus Philip
Abstract excerpt
The human OGG1 (hOGG1) gene encodes a DNA glycosylase that is involved in the excision repair of 8-hydroxy-2'-deoxyguanine (8-OH-dG) from oxidatively-damaged DNA. To determine whether hOGG1 plays a role in risk for orolaryngeal cancer, we screened normal orolaryngeal tissue specimens for hOGG1 expression and assessed the role of the hOGG1 Ser326Cys polymorphism in risk for orolaryngeal cancer. hOGG1 expression...
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