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Article

Modulating the binding properties of an anti-17beta-estradiol antibody by systematic mutation combinations.

Protein science : a publication of the Protein Society - 1 Nov 2003

Lamminmäki Urpo, Westerlund-Karlsson Annette, Toivola Maria, Saviranta Petri

Abstract excerpt

The anti-17beta-estradiol antibody 57-2 has been a subject for several protein engineering studies that have produced a number of mutants with improved binding properties. Here, we generated a set of 16 antibody 57-2 variants by systematically combining mutations previously identified from phage display-derived improved antibody mutants. These mutations included three point mutations in the variable domain of the...

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Identifiers

PMID: 14573866
DOI: 10.1110/ps.0353903
PMCID: PMC2366947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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