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Article

Fine tuning of an anti-testosterone antibody binding site by stepwise optimisation of the CDRs.

Immunotechnology : an international journal of immunological engineering - 1 Jun 1998

Hemminki A, Niemi S, Hautoniemi L, Söderlund H, Takkinen K

Abstract excerpt

BACKGROUND: We have previously reported specificity improvement of an anti-testosterone monoclonal antibody (3-C4F5) by random mutagenesis of the third complementarity determining regions (CDR3s) and by phage display selection. OBJECTIVES: Here we extend the mutagenesis strategy to the other CDRs and select the mutant libraries using two different approaches in order to further fine-tune the binding properties of...

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Source

Identifiers

PMID: 9661815
DOI: 10.1016/s1380-2933(98)00002-5

Genes

TES
CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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