Article
Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population.
European journal of human genetics : EJHG - 1 Nov 2003
Beekman Marian, Heijmans Bastiaan T, Martin Nicholas G, Whitfield John B, Pedersen Nancy L, DeFaire Ulf, Snieder Harold, Lakenberg Nico, Suchiman H Eka D, de Knijff Peter, Frants Rune R, van Ommen Gert Jan B, Kluft Cornelis, Vogler George P, Boomsma Dorret I, Slagboom P Eline
Abstract excerpt
The genetic basis of cardiovascular disease (CVD) with its complex etiology is still largely elusive. Plasma levels of lipids and apolipoproteins are among the major quantitative risk factors for CVD and are well-established intermediate traits that may be more accessible to genetic dissection than clinical CVD end points. Chromosome 19 harbors multiple genes that have been suggested to play a role in lipid...
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