Article
Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents.
Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2006
Eldor R, Yeffet A, Baum K, Doviner V, Amar D, Ben-Neriah Y, Christofori G, Peled A, Carel J C, Boitard C, Klein T, Serup P, Eizirik D L, Melloul D
Abstract excerpt
Type 1 diabetes is characterized by the infiltration of inflammatory cells into pancreatic islets of Langerhans, followed by the selective and progressive destruction of insulin-secreting beta cells. Islet-infiltrating leukocytes secrete cytokines such as IL-1beta and IFN-gamma, which contribute to beta cell death. In vitro evidence suggests that cytokine-induced activation of the transcription factor NF-kappaB...
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